Research and Innovation

Nuvance Health™ conducts groundbreaking research and innovation to improve patient care and advance the field of medicine.

At Nuvance Health, research and innovation are a top priority—unlocking advancements that improve health care now and in the future.

Rudy L. Ruggles Biomedical Research Institute

Renowned scientists perform translational research, which uses scientific findings to improve the standard of patient care and advance our community’s health. Discover more about this groundbreaking work and expertise. Rudy L. Ruggles Biomedical Research Institute

Clinical Trials

Nuvance Health serves as a research site for many national and international clinical trials. Learn how these studies evaluate new approaches to prevent, diagnose and treat disease.

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Lyme Disease Research and Prevention

Researchers educate the public about Lyme disease prevention, developing new diagnostic methods and collaborating on biobanking efforts. Lyme Disease Research and Prevention
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Research and Innovation at Nuvance Health

At Nuvance Health, research and innovation are a top priority—unlocking advancements that improve health care now and in the future. Highlights of the program include:

  • A full range of research initiatives:
    Offerings include translational, clinical and investigator-led research. This robust program is on par with that of major academic medical centers in our region and beyond.
  • Strong research pipeline:
    Sponsors and partner institutions seek out Nuvance Health based on our reputation for solid research. This broad network creates a strong pipeline of opportunities for eligible patients to participate in research.
  • Access to new treatments:
    We provide avenues for patients to be involved in important studies and trials close to home. Eligible patients may have access to promising new therapies before they’re widely available.
  • Career and educational opportunities:
    Nuvance Health offers a launchpad for a rewarding career. We also train the next generation of clinicians and researchers, through internships and fellowships, to make important discoveries.

Clinical trial listing as of April 29, 2021

  • Alzeheimers

    Evoke Plus

    A randomised double-blind placebo-controlled clinical trial investigating the effect and safety of oral semaglutide in subjects with early Alzheimer´s disease (EVOKE plus)

    I5T-MC-AACG

    A Study of LY3002813 in Participants With Early Symptomatic Alzheimer's Disease (TRAILBLAZER-ALZ)

    I5T-MC-AACI

    A Study of Donanemab (LY3002813) in Participants With Early Alzheimer's Disease (TRAILBLAZER-ALZ 2)

  • Arrhythmia

    APPRAISE

    Assessment of Primary Prevention Patients Receiving an Implanted Cardiac Defibrillator – Systematic Evaluation of ATP

    Adapt Response

    The purpose of this clinical study is to test the hypothesis that market released Cardiac Resynchronization Therapy (CRT) devices which contain the AdaptivCRT® (aCRT) algorithm have a superior outcome compared to standard CRT devices in CRT indicated patients with normal atrio-ventricular (AV) conduction and left bundle branch block (LBBB).

    Brady MRI

    The purpose of this post approval study is to evaluate the long-term safety of the FDA approved St. Jude Medical Tendril MRI™ lead implanted with a SJM Brady MRI implantable pulse generator (IPG) such as the Accent MRI™, Assurity MRI™, Endurity MRI™ pacemaker, or similar model (SJM Brady MRI System) in subjects with a standard bradycardia pacing indication.

    Azalea

    A multicenter, Randomized, Active-control study to evaluate the safety and tolerability of two blinded doses of Abenacimab compared with open label rivaroxaban in patients with Atrial Fibrillation

    Product Surveillance Registry

    A Study of Patients with Lower Extremity Acute Limb Ischemia to Remove Thrombus with the Indigo® Aspiration System

  • Cervical Hyperplasia

    Reveal 2

    Randomized Evaluation of VGX-3100 and Electroporation for the Treatment of Cervical HSIL

  • Cognitive Impairment

    NIC

    Long-Term Nicotine Treatment of Mild Cognitive Impairment

  • Coronary Disease

    CLEAR

    Phase III, Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel group study. The purpose of this study is to evaluate whether long term treatment with bempedoic acid, a once a day treatment for cholesterol, reduces the risk of major adverse cardiovascular events in patients with, or at high risk for, cardiovascular disease who are statin intolerant. Reduction in this risk will be assessed with a 5-component major cardiovascular event endpoint, along with clinical endpoints of CV morbidity and mortality and all-cause mortality, in addition to cholesterol levels.

    ECLIPSE

    Evaluation of Treatment Strategies for Severe CaLcIfic Coronary Arteries: Orbital Atherectomy vs. Conventional Angioplasty Technique Prior to Implantation of Drug-Eluting Stents

    HP-4/TIMI 65/ORION 4

    A double-blind, randomized, placebo-controlled trial assessing the effects of inclisiran on clinical outcomes among people with athersclerotic cardiovascular disease.

    Vesalius CV

    A Double-blind, Randomized, Placebo-controlled, Multicenter Study to Evaluate the Impact of Evolocumab on Major Cardiovascular Events in Patients at High Cardiovascular Risk Without Prior Myocardial Infactrion or Stroke

  • COVID-19

    CSSC-004

    Convalescent Plasma to Limit Coronavirus Associated Complications: A Randomized, Double-Blind, Controlled, Phase 2 Study Comparing the Efficacy and Safety of Human Coronavirus Immune Plasma (HCIP) vs. Control (SARS-CoV-2 non-immune) Plasma Among Outpatients with Symptomatic COVID-19. 

    D8110C00001

    A Phase III Randomized, Double-blind, Placebo-controlled Multicenter Study in Adults to Determine the Safety, Efficacy, and Immunogenicity of AZD1222, a Non-replicating ChAdOx1 Vector Vaccine, for the Prevention of COVID-19

    ACTIV 5

    A Multicenter Platform Trial of Putative Therapeutics for the Treatment of COVID-19 in Hospitalized Adults
  • Crohn’s Disease

    M16-000

    A Multicenter, Randomized, Double-Blind, Placebo-Controlled 52-Week Maintenance and an Open-Label Extension Study of the Efficacy and Safety of Risankizumab in Subjects with Crohn's Disease Who Responded to Induction Treatment in M16-006 or M15-991

    M20-259

    A Phase 3, Multicenter, Randomized, Efficacy Assessor-Blinded Study of Risankizumab Compared to Ustekinumab for the Treatment of Adult Subjects with Moderate to Severe Crohn's Disease Who Have Failed Anti-TNF Therapy

  • Diabetes

    Sepra

    Long term comparative effectiveness of once weekly semaglutide versus standard of care in a real-world adult US population with type 2 diabetes - a randomized pragmatic clinical trial

  • Eosinophilic Esophagitis

    FLUTE-2

    Fluticasone propionate Oral Dispersible Tablet Formulation in Eosinophilic Esophagitis: A Two-Part, Randomized, Double-blind, Placebo-Controlled Study of APT-1011 in Adult and Adolescent Subjects with Eosinophilic Esophagiti

  • Giant Cell Arteritis

    M16-852

    A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of Upadacitinib in Subjects with Giant cell Arteritis

  • Heart Failure

    HEART-FID

    A Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Efficacy and Safety of Injectafer® (Ferric Carboxymaltose) as Treatment for Heart Failure with Iron Deficiency

    Carillon

    The objective of this prospective, multi-center, randomized, double-blind trial is to assess the safety and efficacy of the CARILLON Mitral Contour System in treating subjects with functional mitral regurgitation (FMR) associated with heart failure, compared to a randomized Control group which is medically managed according to heart failure guidelines.

    Paraglide HF

    A multicenter, randomized, double-blind, double-dummy, parallel group, active controlled study to evaluate the effect of sacubitril/valsartan (LCZ696) vs. valsartan on changes in NT-proBNP and outcomes, safety and toleratbility in HFpEF patients with acute decompensated heart failure (ADHF) who have ben stabilized duirng hospitalization and initiated in-hospital or within 30 days post discharge.

    GUIDE HF

    The GUIDE-HF IDE clinical trial is intended to demonstrate the effectiveness of the CardioMEMS™ HF System in an expanded patient population including heart failure (HF) patients outside of the present indication, but at risk for future HF events or mortality.

    FINEARTS HF

    A multicenter, randomized, double-blind, parallel-group, placebo-controlled study to evaluate the efficacy and safety of finerenone on morbidity and mortality in participants with heart failure (NYHA II-IV) and left ventricular ejection fraction >40%.

    CORCINCH HF

    Randomized Clinical Evaluation of the AccuCinch Ventricular Restoration System in Patinets who Present with Symtpomatic Heart Filure with Reduced Ejection Fraction (HFrEF).

    DAPA ACT HF/TIMI 68

    This is an international, multicenter, parallel-group, randomized, double-blind, placebo-controlled trial in patients with heart failure with reduced ejection fraction (left ventricular ejection fraction [LVEF] ≤40%) who have been stabilized during hospitalization for acute heart failure, evaluating the effect of in-hospital initiation of dapagliflozin versus placebo on the clinical outcome of cardiovascular death or worsening heart failure

  • Infectious Disease

    CSSC-004

    Convalescent Plasma to Limit Coronavirus Associated Complications: A Randomized, Double-Blind, Controlled, Phase 2 Study Comparing the Efficacy and Safety of Human Coronavirus Immune Plasma (HCIP) vs. Control (SARS-CoV-2 non-immune) Plasma Among Outpatients with Symptomatic COVID-19.

    D8110C00001

    A Phase III Randomized, Double-blind, Placebo-controlled Multicenter Study in Adults to Determine the Safety, Efficacy, and Immunogenicity of AZD1222, a Non-replicating ChAdOx1 Vector Vaccine, for the Prevention of COVID-19

    ACTIV 5/Big Effect Trial (BET)

    A Multicenter Platform Trial of Putative Therapeutics for the Treatment of COVID-19 in Hospitalized Adults.

  • Lupus

    Sable

    A 5-Year Prospective Observational Registry to Assess Adverse Events of Interest and Effectiveness in Adults with Active, Autoantibody-Positive Systemic Lupus Erythematosus Treated with or without Benlysta (belimumab)

  • Migraine

    Post-Authorization Safety Study Protocol (PASS)

    A Long-Term, Prospective, Observational Study to Evaluate the Safety, Including Cardiovascular Safety, of Fremanezumab in Patients with Migraine in Routine Clinical Practice.

     

    Nerivio TCH-008

    A prospective, randomized, double-blind, sham-controlled multi-center clinical study assessing the safety and efficacy of Nerivio for the preventive treatment of migraine

    AMG 334 Erenumab 20190389

    Phase 4 Open Label study to evaluate treatment satisfaction with Erenumab in patients with Migraine

  • Multiple Sclerosis

    VERISMO

    An Observational Study of Ocrelizumab-Treated Patients with Multiple Sclerosis to Determine the Incidence and Mortality Rates of Breast Cancer and All Malignancies

  • Myocardial Infarction

    DalGenE

    Effect of Dalcetrapib vs Placebo on CV Risk in a Genetically Defined Population With a Recent ACS

    Perspective

    A multicenter, randomized, double-blind, active-controlled study to evaluate the effects of LCZ696 compared to valsartan on cognitive function in patients with chronic heart failure and preserved ejection fraction

    NACMI

    North American COVID-19 ST-Segment Elevation Myocardial Infarction (NACMI) Registry

    AEGIS

    A Phase 3, Multicenter, Double-blind, Randomized, Placebo-controlled, Parallel-group Study to Investigate the Efficacy and Safety of CSL112 in Subjects with Acute Coronary Syndrome

  • Parkinson's Disease

    Orchestra

    A Double-Blind, Placebo-controlled, Randomized, 18-month Phase 2A Study to Evaluate the Efficacy, Saety, Tolerability, and Pharmacokinetics of Oral UCB0599 In Study Participants with Early Parkinson's Disease

  • Pulmonary

    LEEP
    Losartan Effects on Emphysema Progression

    CHRONICLE

    A Longitudinal Prospective Observational Study of the Characteristics, Treatment Patterns and Health Outcomes of Individuals with Severe Asthma in the United States.
  • Stroke

    Aspire

    Anticoagulation in ICH Survivors for Stroke Prevention and Recovery (ASPIRE)

  • Valvular

    Optimize PRO

    Optimize PRO TAVR Post Market Study

    Proact XA

    A prospecive, randomized, active (warfarin) controlled, parallel-arm clinical trial to determine if patients with a ON-X aortic valve can be maintained safely and effectively on the factor Xa inhibitor apixaban

  • Vascular

    STRIDE

    A Study of Patients with Lower Extremity Acute Limb Ischemia to Remove Thrombus with the Indigo® Aspiration System

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